Clinical Research Data

With 9 clinical studies (including over 5,500 colposcopy exams), data shows that using DYSIS® Colposcopy with the DYSISmap™ helps increase the detection of patients with high-grade lesions.

Details of the various clinical trials and peer reviewed publications are available below. The US Federal Regulations restricts the display of certain non-US clinical data. Please declare your home country by selecting the appropriate tab below.

  • United States
  • Rest of World

    Clinical Trials

    IMPROVE-COLPO III

    Date: July 16, 2020

    Harris et al., Oncology Letters 20: 17, 2020 This publication presents a sub-analysis of data collected during the IMPROVE-COLPO study, looking specifically at colposcopy patients that had been referred with…

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    Cervical Screening Wales

    Date: May 16, 2018

    Evaluating Colposcopy with Dynamic Spectral Imaging During Routine Practice at Five Colposcopy Clinics in Wales: Clinical Performance Budithi et al, GOI 2018 DYSIS underwent an evaluation in Wales, where it…

    Read More

    IMPROVE-COLPO I

    Date: January 20, 2018

    Cholkeri-Singh et al, Journal of the Lower Genital Tract Disease, 2018 Overview: This publication presents results from the IMPROVE-COLPO, which was designed to observe changes in practice and outcomes after…

    Read More

    IMPROVE-COLPO II

    Date: September 28, 2017

    DeNardis et al, International Journal of Women’s Health 2017 Overview: This publication presents sub-analysis results from the IMPROVE-COLPO study that was designed to assess the detection of women with high-grade…

    Read More

    Cervical Cancer Case Study

    Date: September 28, 2016

    How Colposcopy Misses Invasive Cervical Cancer Livingston and Papagiannakis, Case Reports in Obstetrics and Gynecology, 2016 Overview: A cervical cancer case study, that is used as an example to discuss…

    Read More

    Coronado et al, EJOG, 2015

    Date: October 15, 2015

    Purpose: To study and analyze the diagnostic value of adding Dynamic Spectral Imaging to conventional colposcopy during routine practice. Design: Women with an abnormal screening result had colposcopy with DYSIS.…

    Read More

    Louwers et al, GynOnc, 2015

    Date: October 14, 2015

    A clinical trial on colposcopy with DYSIS was conducted at the outpatient colposcopy clinics of three Dutch hospitals. The performance of Dynamic Spectral Imaging colposcopy depends on indication for referrals.…

    Read More

    IMPROVE (US Clinical Study)

    Date: January 1, 2015

    IMPROVE COLPO − Is the name of the clinical trial that DySIS Medical, Inc. is currently running to investigate the clinical performance of DySIS in comparison to conventional colposcopy. The study…

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    Coronado et al, GOI, 2014

    Date: November 11, 2014

    Correlating the Accuracy of Colposcopy with Practitioner Experience when Diagnosing Cervical Pathology using the Dynamic Spectral Imaging System Background/Aims: To assess the performance of colposcopists and correlate it with their…

    Read More

    Zaal et al, BJOG, 2012

    Date: February 3, 2012

    Agreement between colposcopic impression and histological diagnosis among human papillomavirus type 16-positive women: a clinical trial using dynamic spectral imaging colposcopy For the full publication, please click here.   Overview: A…

    Read More

    Louwers et al, BJOG, 2010

    Date: December 23, 2010

    Dynamic spectral imaging colposcopy: higher sensitivity for detection of premalignant cervical lesions. For the full publication, please click here. Purpose: To validate the ability of a colposcope employing Dynamic Spectral Imaging…

    Read More

    Published Articles/Abstracts

    Challenges and improvements in colposcopy on a post-treatment patient with carcinoma in situ

    Date: March 9, 2015

    Challenges and improvements in colposcopy on a post-treatment patient with carcinoma in situ Background: Women treated for cervical dysplasia are co-tested (cytology/high-risk human papillomavirus) at 12/24 months. Those with a…

    Read More

    Dynamic Spectral Imaging for triage of Low Grades

    Date: May 26, 2014

    Poster Presentation at IFCPC (London, 2014) Background: Women with Low-Grade (LG) smears who are high-risk (HR) HPV positive have a 16% chance of underlying CIN2+. In addition, data from the…

    Read More

    The correlation between size of colposcopic lesions and the histological grade, using various colposcopy methods

    Date: May 26, 2014

    Poster presentation at IFCPC (London, 2014) Background Since its evolution in 1924, colposcopy has developed through the decades. Along with the use of directed biopsies, it has become an established…

    Read More

    Dynamic Spectral Imaging for Post-Treatment Triage

    Date: May 26, 2014

    Poster Presentation at IFCPC (London, 2014) Poster 237 – Dr Christina Founta : Dynamic Spectral Imaging for Post-Treatment Triage. Background: The UK NHSCSP (National Health Service Cervical Screening Programme) recently…

    Read More

    Adjunctive colposcopy technologies for examination of the uterine cervix

    Date: March 17, 2013

    Adjunctive colposcopy technologies for examination of the uterine cervix–DYSIS, LuViva Advanced Cervical Scan and Niris Imaging System: a systematic review and economic evaluation. Wade R, Spackman E, Corbett M, Walker…

    Read More

    NICE Guidance Document

    Date: December 11, 2012

    NICE 2012 Guidance Document (National Institute for Health and Care Excellence). Adjunctive colposcopy technologies for examination of the uterine cervix – DYSIS and the Niris Imaging System (December 11, 2012) http://publications.nice.org.uk/adjunctive-colposcopy- technologies-for-examination-of-the-uterine-cervix-dysis-and-the-niris-dg4

    Read More

    Clinical Trials

    IMPROVE-COLPO III

    Date: July 16, 2020

    Harris et al., Oncology Letters 20: 17, 2020 This publication presents a sub-analysis of data collected during the IMPROVE-COLPO study, looking specifically at colposcopy patients that had been referred with…

    Read More

    Cervical Screening Wales

    Date: May 16, 2018

    Evaluating Colposcopy with Dynamic Spectral Imaging During Routine Practice at Five Colposcopy Clinics in Wales: Clinical Performance Budithi et al, GOI 2018 DYSIS underwent an evaluation in Wales, where it…

    Read More

    IMPROVE-COLPO I

    Date: January 20, 2018

    Cholkeri-Singh et al, Journal of the Lower Genital Tract Disease, 2018 Overview: This publication presents results from the IMPROVE-COLPO, which was designed to observe changes in practice and outcomes after…

    Read More

    IMPROVE-COLPO II

    Date: September 28, 2017

    DeNardis et al, International Journal of Women’s Health 2017 Overview: This publication presents sub-analysis results from the IMPROVE-COLPO study that was designed to assess the detection of women with high-grade…

    Read More

    Cervical Cancer Case Study

    Date: September 28, 2016

    How Colposcopy Misses Invasive Cervical Cancer Livingston and Papagiannakis, Case Reports in Obstetrics and Gynecology, 2016 Overview: A cervical cancer case study, that is used as an example to discuss…

    Read More

    Coronado et al, EJOG, 2015

    Date: October 15, 2015

    Purpose: To study and analyze the diagnostic value of adding Dynamic Spectral Imaging to conventional colposcopy during routine practice. Design: Women with an abnormal screening result had colposcopy with DYSIS.…

    Read More

    Louwers et al, GynOnc, 2015

    Date: October 14, 2015

    A clinical trial on colposcopy with DYSIS was conducted at the outpatient colposcopy clinics of three Dutch hospitals. The performance of Dynamic Spectral Imaging colposcopy depends on indication for referrals.…

    Read More

    Coronado et al, GOI, 2014

    Date: November 11, 2014

    Correlating the Accuracy of Colposcopy with Practitioner Experience when Diagnosing Cervical Pathology using the Dynamic Spectral Imaging System Background/Aims: To assess the performance of colposcopists and correlate it with their…

    Read More

    Zaal et al, BJOG, 2012

    Date: February 3, 2012

    Agreement between colposcopic impression and histological diagnosis among human papillomavirus type 16-positive women: a clinical trial using dynamic spectral imaging colposcopy For the full publication, please click here.   Overview: A…

    Read More

    Louwers et al, BJOG, 2010

    Date: December 23, 2010

    Dynamic spectral imaging colposcopy: higher sensitivity for detection of premalignant cervical lesions. For the full publication, please click here. Purpose: To validate the ability of a colposcope employing Dynamic Spectral Imaging…

    Read More

    Soutter et al, CCR, 2009

    Date: February 17, 2009

      Dynamic Spectral Imaging: Improving Colposcopy Soutter et al, Clinical Cancer Research 2009 For the full publication, please click here. Objective: To compare the objective and quantified approach of Dynamic Spectral…

    Read More

    Published Articles/Abstracts

    Patient experience & reassurance after colposcopy with DYSIS

    Date: May 2, 2016

    Poster Presentation - BSCCP 2016 Patient reassurance after DYSIS – click to view

    Read More

    Challenges and improvements in colposcopy on a post-treatment patient with carcinoma in situ

    Date: March 9, 2015

    Challenges and improvements in colposcopy on a post-treatment patient with carcinoma in situ Background: Women treated for cervical dysplasia are co-tested (cytology/high-risk human papillomavirus) at 12/24 months. Those with a…

    Read More

    Dynamic Spectral Imaging for triage of Low Grades

    Date: May 26, 2014

    Poster Presentation at IFCPC (London, 2014) Background: Women with Low-Grade (LG) smears who are high-risk (HR) HPV positive have a 16% chance of underlying CIN2+. In addition, data from the…

    Read More

    The correlation between size of colposcopic lesions and the histological grade, using various colposcopy methods

    Date: May 26, 2014

    Poster presentation at IFCPC (London, 2014) Background Since its evolution in 1924, colposcopy has developed through the decades. Along with the use of directed biopsies, it has become an established…

    Read More

    Dynamic Spectral Imaging for Post-Treatment Triage

    Date: May 26, 2014

    Poster Presentation at IFCPC (London, 2014) Poster 237 – Dr Christina Founta : Dynamic Spectral Imaging for Post-Treatment Triage. Background: The UK NHSCSP (National Health Service Cervical Screening Programme) recently…

    Read More

    Adjunctive colposcopy technologies for examination of the uterine cervix

    Date: March 17, 2013

    Adjunctive colposcopy technologies for examination of the uterine cervix–DYSIS, LuViva Advanced Cervical Scan and Niris Imaging System: a systematic review and economic evaluation. Wade R, Spackman E, Corbett M, Walker…

    Read More

    NICE Guidance Document

    Date: December 11, 2012

    NICE 2012 Guidance Document (National Institute for Health and Care Excellence). Adjunctive colposcopy technologies for examination of the uterine cervix – DYSIS and the Niris Imaging System (December 11, 2012) http://publications.nice.org.uk/adjunctive-colposcopy- technologies-for-examination-of-the-uterine-cervix-dysis-and-the-niris-dg4

    Read More

    Digital Colposcopy ready for use?

    Date: January 11, 2009

    Digital colposcopy: ready for use? An overview of literature JA Louwers, M Kocken, WA ter Harmsel and RHM Verheijen BJOG 2009 Jan; 116(2):220-29 http://www.ncbi.nlm.nih.gov/pubmed/19076954

    Read More