Low-Grade Cytology Referral – DYSIS Medical

Low-Grade Cytology Referral

DYSIS assisted the clinician to identify a location for biopsy that revealed a CIN2 lesion on a 27 year old patient with Low-Grade cytology.

Low-Grade Cytology Referral

Patient Background:

27 years old (smoker: unknown)

Referred with a Borderline/hrHPV test result

Colposcopic impression was that of Low-Grade changes

DYSISmap highlighted focal suspicious area

Colposcopically directed biopsy (#1): Normal/HPV changes

DYSISmap directed biopsy (#2): CIN2

The subsequent conization (LLETZ) revealed CIN1; apparently the damage had been removed by the punch biopsy process

The colposcopist selected to biopsy at 12 o’clock (white circle), but after seeing the DYSISmap, also identied 6 o’clock (yellow circle) as an important biopsy site. The biopsy 1 returned histology showing HPV changes only; whereas the biopsy location 2, indicated by the DYSISmap was CIN2. According to the UK guidelines for managing women at colposcopy, with only biopsy 1 as a reference, this HPV-positive patient would have been released to 3-yearly routine screening creating a risk of disease progression.

Acetowhitening Effect

Acetowhitening Effect